Heritability of Parkinson disease in Swedish twins: a longitudinal study.
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ABSTRACT:
SUBMITTER: Wirdefeldt K
PROVIDER: S-EPMC4452894 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Heritability of Parkinson disease in Swedish twins: a longitudinal study.
Wirdefeldt Karin K Gatz Margaret M Reynolds Chandra A CA Prescott Carol A CA Pedersen Nancy L NL
Neurobiology of aging 20110411 10
Previous twin studies report no heritability of Parkinson's disease (PD) based on cross sectional information. Here, we apply a longitudinal design and re-evaluate cross sectional data in the population-based Swedish Twin Registry (STR) using clinical as well as hospital discharge and cause of death diagnoses. In the longitudinal analyses (based on 46,436 individuals), we identified 542 twins with PD and 65 twins with Parkinsonism. Concordance rates for PD were 11% for monozygotic and 4% for sam ...[more]
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