Ontology highlight
ABSTRACT:
SUBMITTER: Komatsu S
PROVIDER: S-EPMC4453442 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Komatsu S S Ichikawa D D Hirajima S S Nagata H H Nishimura Y Y Kawaguchi T T Miyamae M M Okajima W W Ohashi T T Konishi H H Shiozaki A A Fujiwara H H Okamoto K K Tsuda H H Imoto I I Inazawa J J Otsuji E E
British journal of cancer 20141016 2
<h4>Background</h4>SET and MYND domain-containing protein 2 (SMYD2) is a lysine methyltransferase for histone H3, p53 and Rb and inhibits their transactivation activities. In this study, we tested whether SMYD2 (1q42) acts as a cancer-promoting factor by being overexpressed in gastric cancer.<h4>Methods</h4>We analysed 7 gastric cancer cell lines and 147 primary tumor samples of gastric cancer, which were curatively resected in our hospital.<h4>Results</h4>SET and MYND domain-containing protein ...[more]