Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark.
Ontology highlight
ABSTRACT: Background
Evidence is conflicting regarding statin use and risk of basal cell (BCC) and squamous cell skin cancer (SCC).Methods
Using Danish nationwide registries, we identified all patients with incident BCC/SCC during 2005-2009 and matched them to population controls. We computed odds ratios (ORs) for BCC and SCC associated with statin use.Results
We identified 38,484 cases of BCC and 3724 cases of SCC. Statin ever use was associated with ORs of 1.09 (CI: 1.06-1.13) for BCC and 1.01 (CI: 0.91-1.11) for SCC.Conclusions
Statin use was not associated with risk of SCC. Residual confounding plausibly explains the marginally increased risk of BCC.
SUBMITTER: Arnspang S
PROVIDER: S-EPMC4453598 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Statin use and risk of nonmelanoma skin cancer: a nationwide study in Denmark.
Arnspang S S Pottegård A A Friis S S Clemmensen O O Andersen K E KE Hallas J J Gaist D D
British journal of cancer 20141007 1
<h4>Background</h4>Evidence is conflicting regarding statin use and risk of basal cell (BCC) and squamous cell skin cancer (SCC).<h4>Methods</h4>Using Danish nationwide registries, we identified all patients with incident BCC/SCC during 2005-2009 and matched them to population controls. We computed odds ratios (ORs) for BCC and SCC associated with statin use.<h4>Results</h4>We identified 38,484 cases of BCC and 3724 cases of SCC. Statin ever use was associated with ORs of 1.09 (CI: 1.06-1.13) fo ...[more]
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