Physical function as a prognostic biomarker among cancer survivors.
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ABSTRACT: Background
We tested the hypothesis that objectively measured physical function predicts mortality among cancer survivors.Methods
We assessed objectively measured physical function including the short physical performance battery (SPPB) and fast walk speed in older adult cancer survivors.Results
Among 413 cancer survivors, 315 (76%) died during a median follow-up of 11.0 years. In multivariable-adjusted analyses, each 1-unit increase in the SPPB score and 0.1?m?s(-1) increase in fast walk speed predicted a 12% reduction in mortality (hazard ratio (HR): 0.88 (95% confidence interval (CI): 0.82-0.94); P<0.001, and HR: 0.88 (95% CI: 0.82-0.96); P=0.003, respectively).Conclusions
Objectively measured physical function may predict mortality among cancer survivors.
SUBMITTER: Brown JC
PROVIDER: S-EPMC4453612 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Physical function as a prognostic biomarker among cancer survivors.
Brown J C JC Harhay M O MO Harhay M N MN
British journal of cancer 20141113 1
<h4>Background</h4>We tested the hypothesis that objectively measured physical function predicts mortality among cancer survivors.<h4>Methods</h4>We assessed objectively measured physical function including the short physical performance battery (SPPB) and fast walk speed in older adult cancer survivors.<h4>Results</h4>Among 413 cancer survivors, 315 (76%) died during a median follow-up of 11.0 years. In multivariable-adjusted analyses, each 1-unit increase in the SPPB score and 0.1 m s(-1) incr ...[more]
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