Sunitinib re-challenge in advanced renal-cell carcinoma.
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ABSTRACT:
SUBMITTER: Porta C
PROVIDER: S-EPMC4453836 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Sunitinib re-challenge in advanced renal-cell carcinoma.
Porta C C Paglino C C Grünwald V V
British journal of cancer 20140506 6
Despite offering significant clinical benefits in advanced renal-cell carcinoma (RCC), the effectiveness of targeted therapies eventually declines with the development of resistance. Defining optimal sequences of therapy is therefore the focus of much current research. There is also evidence that treatment 're-challenge' may be an effective strategy in some patients. We review evidence to evaluate whether sunitinib may have value as re-challenge therapy in patients who have progressed on prior t ...[more]
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