Ontology highlight
ABSTRACT:
SUBMITTER: Di Martino MT
PROVIDER: S-EPMC4453928 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Di Martino Maria T MT Leone Emanuela E Amodio Nicola N Foresta Umberto U Lionetti Marta M Pitari Maria R MR Cantafio Maria E Gallo ME Gullà Annamaria A Conforti Francesco F Morelli Eugenio E Tomaino Vera V Rossi Marco M Negrini Massimo M Ferrarini Manlio M Caraglia Michele M Shammas Masood A MA Munshi Nikhil C NC Anderson Kenneth C KC Neri Antonino A Tagliaferri Pierosandro P Tassone Pierfrancesco P
Clinical cancer research : an official journal of the American Association for Cancer Research 20121003 22
<h4>Purpose</h4>Deregulated expression of miRNAs has been shown in multiple myeloma (MM). A promising strategy to achieve a therapeutic effect by targeting the miRNA regulatory network is to enforce the expression of miRNAs that act as tumor suppressor genes, such as miR-34a.<h4>Experimental design</h4>Here, we investigated the therapeutic potential of synthetic miR-34a against human MM cells in vitro and in vivo.<h4>Results</h4>Either transient expression of miR-34a synthetic mimics or lentivir ...[more]