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Engineering cytochrome-modified silica nanoparticles to induce programmed cell death.

ABSTRACT: A low native membrane permeability and ineffective access to the cellular cytosol, together with aggressive proteolytic degradation, often severely hampers the practical application of any therapeutic protein or antibody. Through engineering the charging profile of mesoporous silica nanoparticles, cellular uptake and subsequent subcellular distribution can be controlled. We show herein that programmed cell death can subsequently be induced across a population of cancer cells with remarkable efficacy on conjugating a specific caspase-cascade-activating cytochrome to such cytosol-accessing particles.

SUBMITTER: Huang WY

PROVIDER: S-EPMC4454278 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Engineering cytochrome-modified silica nanoparticles to induce programmed cell death.

Huang Wen-Yen WY Davies Gemma-Louise GL Davis Jason J JJ

Chemistry (Weinheim an der Bergstrasse, Germany) 20131118 52

A low native membrane permeability and ineffective access to the cellular cytosol, together with aggressive proteolytic degradation, often severely hampers the practical application of any therapeutic protein or antibody. Through engineering the charging profile of mesoporous silica nanoparticles, cellular uptake and subsequent subcellular distribution can be controlled. We show herein that programmed cell death can subsequently be induced across a population of cancer cells with remarkable effi ...[more]

PMID: 24249039

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