Ontology highlight
ABSTRACT:
SUBMITTER: Tan MS
PROVIDER: S-EPMC4454321 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Tan M-S MS Tan L L Jiang T T Zhu X-C XC Wang H-F HF Jia C-D CD Yu J-T JT
Cell death & disease 20140821
Increasing evidence has shown the aberrant expression of inflammasome-related proteins in Alzheimer's disease (AD) brain; these proteins, including NLRP1 inflammasome, are implicated in the execution of inflammatory response and pyroptotic death. Although current data are associated NLRP1 genetic variants with AD, the involvement of NLRP1 inflammasome in AD pathogenesis is still unknown. Using APPswe/PS1dE9 transgenic mice, we found that cerebral NLRP1 levels were upregulated. Our in vitro studi ...[more]