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Super-secondary structure peptidomimetics: design and synthesis of an ?-? hairpin analogue.

ABSTRACT: The ?-? helix motif presents key recognition domains in protein-protein and protein-oligonucleotide binding, and is one of the most common super-secondary structures. Herein we describe the design, synthesis and structural characterization of an ?-? hairpin analogue based on a tetra-coordinated Pd(II) bis-(iminoisoquinoline) complex as a template for the display of two ?-helix mimics. This approach is exemplified by the attachment of two biphenyl peptidomimetics to reproduce the side-chains of the i and i+4 residues of two helices.

SUBMITTER: Nevola L

PROVIDER: S-EPMC4454340 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Super-secondary structure peptidomimetics: design and synthesis of an α-α hairpin analogue.

Nevola Laura L Rodriguez Johanna M JM Thompson Sam S Hamilton Andrew D AD

Supramolecular chemistry 20130901 9-11

The α-α helix motif presents key recognition domains in protein-protein and protein-oligonucleotide binding, and is one of the most common super-secondary structures. Herein we describe the design, synthesis and structural characterization of an α-α hairpin analogue based on a tetra-coordinated Pd(II) <i>bis</i>-(iminoisoquinoline) complex as a template for the display of two α-helix mimics. This approach is exemplified by the attachment of two biphenyl peptidomimetics to reproduce the side-chai ...[more]

PMID: 26052191

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