Ontology highlight
ABSTRACT:
SUBMITTER: Girard SL
PROVIDER: S-EPMC4454531 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Girard Simon L SL Dion Patrick A PA Bourassa Cynthia V CV Geoffroy Steve S Lachance-Touchette Pamela P Barhdadi Amina A Langlois Mathieu M Joober Ridha R Krebs Marie-Odile MO Dubé Marie-Pierre MP Rouleau Guy A GA
PloS one 20150603 6
<h4>Background</h4>Schizophrenia (SCZ) is a very heterogeneous disease that affects approximately 1% of the general population. Recently, the genetic complexity thought to underlie this condition was further supported by three independent studies that identified an increased number of damaging de novo mutations DNM in different SCZ probands. While these three reports support the implication of DNM in the pathogenesis of SCZ, the absence of overlap in the genes identified suggests that the number ...[more]