Dataset Information

Sex Differences in the Effects of Weight Loss Diets on Bone Mineral Density and Body Composition: POUNDS LOST Trial.

ABSTRACT:

Context

Weight loss is associated with reduction in bone mineral density (BMD).

Objective

The objective was to address the role of changes in fat mass (FM) and lean mass (LM) in BMD decline in both sexes.

Design

A 2-year randomized controlled trial, the Preventing Overweight Using Novel Dietary Strategies (POUNDS-LOST).

Setting

The setting was the general community.

Patients or other participants

Enrolled were 424 overweight and obese participants (mean age, 52 ± 9 y; 57% females).

Intervention

Intervention included weight loss diets differing in fat, protein, and carbohydrates.

Main outcome measures

Main outcome measures were change in spine, total hip (TH), and femoral neck (FN) BMD and sex differences after dietary intervention.

Results

At baseline, a stronger correlation between BMD and body composition measurements was observed in women, primarily with LM (r = 0.419, 0.507, and 0.523 for spine, FN, and TH, respectively; all P < .001). In men, only LM correlated with hip BMD (r = 0.298; P < .001). Mean weight loss at 2 years was -6.9%, without differences among diets. Two-year changes in BMD were 0.005 (P = .04), -0.014 (P < .001), and -0.014 g/cm(2) (P < .001), at the spine, TH, and FN, respectively. These changes directly correlated with changes in LM in women (r = 0.200, 0.324, and 0.260 for spine, FN, and TH, respectively), whereas FM loss correlated only with changes in TH BMD (0.274; P < .001). In men, changes in LM (-0.323; P < .001) and FM (-0.213; P = .027) negatively correlated with changes in spine BMD.

Conclusions

Weight loss diets result in sex-specific effects on BMD. Although men exhibited a paradoxical increase in spine BMD, women tended to decrease in BMD at all sites.

SUBMITTER: Tirosh A

PROVIDER: S-EPMC4454797 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Publications

Sex Differences in the Effects of Weight Loss Diets on Bone Mineral Density and Body Composition: POUNDS LOST Trial.

Tirosh Amir A de Souza Russell J RJ Sacks Frank F Bray George A GA Smith Steven R SR LeBoff Meryl S MS

The Journal of clinical endocrinology and metabolism 20150331 6

<h4>Context</h4>Weight loss is associated with reduction in bone mineral density (BMD).<h4>Objective</h4>The objective was to address the role of changes in fat mass (FM) and lean mass (LM) in BMD decline in both sexes.<h4>Design</h4>A 2-year randomized controlled trial, the Preventing Overweight Using Novel Dietary Strategies (POUNDS-LOST).<h4>Setting</h4>The setting was the general community.<h4>Patients or other participants</h4>Enrolled were 424 overweight and obese participants (mean age, 5 ...[more]

PMID: 25825948

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Dataset Information

Sex Differences in the Effects of Weight Loss Diets on Bone Mineral Density and Body Composition: POUNDS LOST Trial.

Context

Objective

Design

Setting

Patients or other participants

Intervention

Main outcome measures

Results

Conclusions

Publications

Sex Differences in the Effects of Weight Loss Diets on Bone Mineral Density and Body Composition: POUNDS LOST Trial.

Similar Datasets

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