Ontology highlight
ABSTRACT:
SUBMITTER: Chen JL
PROVIDER: S-EPMC4455060 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Chen Jonathan L JL Kennedy Scott D SD Turner Douglas H DH
Biochemistry 20150521 21
Influenza A is an RNA virus with a genome of eight negative sense segments. Segment 7 mRNA contains a 3' splice site for alternative splicing to encode the essential M2 protein. On the basis of sequence alignment and chemical mapping experiments, the secondary structure surrounding the 3' splice site has an internal loop, adenine bulge, and hairpin loop when it is in the hairpin conformation that exposes the 3' splice site. We report structural features of a three-dimensional model of the hairpi ...[more]