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Quality of antimalarials at the epicenter of antimalarial drug resistance: results from an overt and mystery client survey in Cambodia.


ABSTRACT: Widespread availability of monotherapies and falsified antimalarials is thought to have contributed to the historical development of multidrug-resistant malaria in Cambodia. This study aimed to document the quality of artemisinin-containing antimalarials (ACAs) and to compare two methods of collecting antimalarials from drug outlets: through open surveyors and mystery clients (MCs). Few oral artemisinin-based monotherapies and no suspected falsified medicines were found. All 291 samples contained the stated active pharmaceutical ingredient (API) of which 69% were considered good quality by chemical analysis. Overall, medicine quality did not differ by collection method, although open surveyors were less likely to obtain oral artemisinin-based monotherapies than MCs. The results are an encouraging indication of the positive impact of the country's efforts to tackle falsified antimalarials and artemisinin-based monotherapies. However, poor-quality medicines remain an ongoing challenge that demands sustained political will and investment of human and financial resources.

SUBMITTER: Yeung S 

PROVIDER: S-EPMC4455075 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Quality of antimalarials at the epicenter of antimalarial drug resistance: results from an overt and mystery client survey in Cambodia.

Yeung Shunmay S   Lawford Harriet L S HLS   Tabernero Patricia P   Nguon Chea C   van Wyk Albert A   Malik Naiela N   DeSousa Mikhael M   Rada Ouk O   Boravann Mam M   Dwivedi Prabha P   Hostetler Dana M DM   Swamidoss Isabel I   Green Michael D MD   Fernandez Facundo M FM   Kaur Harparkash H  

The American journal of tropical medicine and hygiene 20150420 6 Suppl


Widespread availability of monotherapies and falsified antimalarials is thought to have contributed to the historical development of multidrug-resistant malaria in Cambodia. This study aimed to document the quality of artemisinin-containing antimalarials (ACAs) and to compare two methods of collecting antimalarials from drug outlets: through open surveyors and mystery clients (MCs). Few oral artemisinin-based monotherapies and no suspected falsified medicines were found. All 291 samples containe  ...[more]

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