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Pathway-based gene signatures predicting clinical outcome of lung adenocarcinoma.


ABSTRACT: Lung adenocarcinoma is often diagnosed at an advanced stage with poor prognosis. Patients with different clinical outcomes may have similar clinico-pathological characteristics. The results of previous studies for biomarkers for lung adenocarcinoma have generally been inconsistent and limited in clinical application. In this study, we used inverse-variance weighting to combine the hazard ratios for the four datasets and performed pathway analysis to identify prognosis-associated gene signatures. A total of 2,418 genes were found to be significantly associated with overall survival. Of these, a 21-gene signature in the HMGB1/RAGE signalling pathway and a 31-gene signature in the clathrin-coated vesicle cycle pathway were significantly associated with prognosis of lung adenocarcinoma across all four datasets (all p-values?

SUBMITTER: Chang YH 

PROVIDER: S-EPMC4455286 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Pathway-based gene signatures predicting clinical outcome of lung adenocarcinoma.

Chang Ya-Hsuan YH   Chen Chung-Ming CM   Chen Hsuan-Yu HY   Yang Pan-Chyr PC  

Scientific reports 20150604


Lung adenocarcinoma is often diagnosed at an advanced stage with poor prognosis. Patients with different clinical outcomes may have similar clinico-pathological characteristics. The results of previous studies for biomarkers for lung adenocarcinoma have generally been inconsistent and limited in clinical application. In this study, we used inverse-variance weighting to combine the hazard ratios for the four datasets and performed pathway analysis to identify prognosis-associated gene signatures.  ...[more]

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