The Ankyrin Repeat Domain 49 (ANKRD49) Augments Autophagy of Serum-Starved GC-1 Cells through the NF-?B Pathway.
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ABSTRACT:
SUBMITTER: Wang HL
PROVIDER: S-EPMC4455995 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
The Ankyrin Repeat Domain 49 (ANKRD49) Augments Autophagy of Serum-Starved GC-1 Cells through the NF-κB Pathway.
Wang Hai-long HL Fan Sha-sha SS Pang Min M Liu Yi-heng YH Guo Min M Liang Jun-bo JB Zhang Jian-lin JL Yu Bao-feng BF Guo Rui R Xie Jun J Zheng Guo-ping GP
PloS one 20150604 6
The ankyrin repeat domain 49 (ANKRD49) is an evolutionarily conserved protein highly expressed in testes. However, the function of ANKRD49 in spermatogenesis is unknown. In this study, we found that ANKRD49 resides primarily in nucleus of spermatogonia, spermatocytes and round spermatids. ANKRD49 overexpression augments starvation-induced autophagy in male germ GC-1 cells whereas shRNA knockdown of ANKRD49 attenuates the autophagy. Inhibition of NF-κB pathway by its inhibitors or p65 siRNA preve ...[more]
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