Ontology highlight
ABSTRACT:
SUBMITTER: Tsukada T
PROVIDER: S-EPMC4456156 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Tsukada Tsuyoshi T Simamura Eriko E Shimada Hiroki H Arai Takuma T Higashi Nobuaki N Akai Takuya T Iizuka Hideaki H Hatta Toshihisa T
PloS one 20150604 6
Recent studies in rodents suggest that maternal immune activation (MIA) by viral infection is associated with schizophrenia and autism in offspring. Although maternal IL-6 is though t to be a possible mediator relating MIA induced these neuropsychiatric disorders, the mechanism remains to be elucidated. Previously, we reported that the maternal leukemia inhibitory factor (LIF)-placental ACTH-fetal LIF signaling relay pathway (maternal-fetal LIF signal relay) promotes neurogenesis of fetal cerebr ...[more]