Ontology highlight
ABSTRACT:
SUBMITTER: Qiu Y
PROVIDER: S-EPMC4456222 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Qiu Yupeng Y Niu Hengyao H Vukovic Lela L Sung Patrick P Myong Sua S
Structure (London, England : 1993) 20150521 6
Trinucleotide repeat (TNR) expansion is the root cause for many known congenital neurological and muscular disorders in human including Huntington's disease, fragile X syndrome, and Friedreich's ataxia. The stable secondary hairpin structures formed by TNR may trigger fork stalling during replication, causing DNA polymerase slippage and TNR expansion. Srs2 and Sgs1 are two helicases in yeast that resolve TNR hairpins during DNA replication and prevent genome expansion. Using single-molecule fluo ...[more]