Computational tools for epitope vaccine design and evaluation.
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ABSTRACT:
SUBMITTER: He L
PROVIDER: S-EPMC4456225 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Computational tools for epitope vaccine design and evaluation.
Current opinion in virology 20150331
Rational approaches will be required to develop universal vaccines for viral pathogens such as human immunodeficiency virus, hepatitis C virus, and influenza, for which empirical approaches have failed. The main objective of a rational vaccine strategy is to design novel immunogens that are capable of inducing long-term protective immunity. In practice, this requires structure-based engineering of the target neutralizing epitopes and a quantitative readout of vaccine-induced immune responses. Th ...[more]
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