Ontology highlight
ABSTRACT:
SUBMITTER: Brosey CA
PROVIDER: S-EPMC4456234 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20150521 6
Replication Protein A (RPA) is an essential scaffold for many DNA processing machines; its function relies on its modular architecture. Here, we report (15)N-nuclear magnetic resonance heteronuclear relaxation analysis to characterize the movements of single-stranded (ss) DNA binding and protein interaction modules in the RPA70 subunit. Our results provide direct evidence for coordination of the motion of the tandem RPA70AB ssDNA binding domains. Moreover, binding of ssDNA substrate is found to ...[more]