Ontology highlight
ABSTRACT:
SUBMITTER: Jinn S
PROVIDER: S-EPMC4456254 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Jinn Sarah S Brandis Katrina A KA Ren Aileen A Chacko Anita A Dudley-Rucker Nicole N Gale Sarah E SE Sidhu Rohini R Fujiwara Hideji H Jiang Hui H Olsen Brett N BN Schaffer Jean E JE Ory Daniel S DS
Cell metabolism 20150514 6
Cholesterol is required for the growth and viability of mammalian cells and is an obligate precursor for steroid hormone synthesis. Using a loss-of-function screen for mutants with defects in intracellular cholesterol trafficking, a Chinese hamster ovary cell mutant with haploinsufficiency of the U17 snoRNA was isolated. U17 is an H/ACA orphan snoRNA, for which a function other than ribosomal processing has not previously been identified. Through expression profiling, we identified hypoxia-upreg ...[more]