Ontology highlight
ABSTRACT:
SUBMITTER: Nowak DG
PROVIDER: S-EPMC4456272 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Nowak Dawid G DG Cho Hyejin H Herzka Tali T Watrud Kaitlin K DeMarco Daniel V DV Wang Victoria M Y VM Senturk Serif S Fellmann Christof C Ding David D Beinortas Tumas T Kleinman David D Chen Muhan M Sordella Raffaella R Wilkinson John E JE Castillo-Martin Mireia M Cordon-Cardo Carlos C Robinson Brian D BD Trotman Lloyd C LC
Cancer discovery 20150331 6
<h4>Unlabelled</h4>We have recently recapitulated metastasis of human PTEN/TP53-mutant prostate cancer in the mouse using the RapidCaP system. Surprisingly, we found that this metastasis is driven by MYC, and not AKT, activation. Here, we show that cell-cell communication by IL6 drives the AKT-MYC switch through activation of the AKT-suppressing phosphatase PHLPP2, when PTEN and p53 are lost together, but not separately. IL6 then communicates a downstream program of STAT3-mediated MYC activation ...[more]