Ontology highlight
ABSTRACT:
SUBMITTER: Kinde MN
PROVIDER: S-EPMC4456284 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Kinde Monica N MN Chen Qiang Q Lawless Matthew J MJ Mowrey David D DD Xu Jiawei J Saxena Sunil S Xu Yan Y Tang Pei P
Structure (London, England : 1993) 20150507 6
Structural rearrangements underlying functional transitions of pentameric ligand-gated ion channels (pLGICs) are not fully understood. Using (19)F nuclear magnetic resonance and electron spin resonance spectroscopy, we found that ELIC, a pLGIC from Erwinia chrysanthemi, expanded the extracellular end and contracted the intracellular end of its pore during transition from the resting to an apparent desensitized state. Importantly, the contraction at the intracellular end of the pore likely forms ...[more]