Lectin-gated, mesoporous, photofunctionalized glyconanoparticles for glutathione-responsive drug delivery.
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ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC4456355 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Lectin-gated, mesoporous, photofunctionalized glyconanoparticles for glutathione-responsive drug delivery.
Zhou Juan J Hao Nanjing N De Zoyza Thareendra T Yan Mingdi M Ramström Olof O
Chemical communications (Cambridge, England) 20150601 48
A stimuli-responsive drug delivery system based on fluorescent, lectin-gated, mesoporous glyconanoparticles has been developed and evaluated in normal- and cancer lung epithelial cells. The gating process proved efficient, exhibiting good sealing properties in the absence of the glutathione redox trigger, avoiding premature release in normal cells. In the presence of higher levels of glutathione in cancer cells, the lectin gate was rapidly opened and the anticancer drug released. ...[more]
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