Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC4456380 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Liu Chunyan C Mei Wenjuan W Tang Juan J Yuan Qiongjing Q Huang Ling L Lu Miaomiao M Wu Lin L Peng Zhangzhe Z Meng Jie J Yang Huixiang H Shen Hong H Lv Ben B Hu Gaoyun G Tao Lijian L
PloS one 20150604 6
<h4>Background</h4>Inflammation has a crucial role in renal interstitial fibrosis, which is the common pathway of chronic kidney diseases. Mefunidone (MFD) is a new compound which could effectively inhibit the proliferation of renal fibroblasts in vitro. However, the overall effect of Mefunidone in renal fibrosis remains unknown.<h4>Methods</h4>Sprague-Dawley rats were randomly divided intro 6 groups: sham operation, unilateral ureteral obstruction (UUO), UUO/Mefunidone (25, 50, 100mg/kg/day) an ...[more]