Association between tumour necrosis factor-α inhibitors and risk of serious infections in people with inflammatory bowel disease: nationwide Danish cohort study.

ABSTRACT:

Objective

To investigate whether people with inflammatory bowel disease treated with tumour necrosis factor-α (TNF-α) inhibitors are at increased risk of serious infections.

Design

Nationwide register based propensity score matched cohort study.

Setting

Denmark, 2002-12.

Participants

The background cohort eligible for matching comprised 52,392 people with inflammatory bowel disease, aged 15 to 75 years, of whom 4300 were treated with TNF-α inhibitors. To limit confounding, a two stage matching method was applied; firstly matching on age, sex, disease duration, and inflammatory bowel disease subtype, and secondly matching on propensity scores (1:1 ratio); this yielded 1543 people treated with TNF-α inhibitors and 1543 untreated to be included in the analyses.

SUBMITTER: Nyboe Andersen N 

PROVIDER: S-EPMC4456959 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature