Ontology highlight
ABSTRACT:
SUBMITTER: Hannan TJ
PROVIDER: S-EPMC4457352 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Hannan Thomas J TJ Roberts Pacita L PL Riehl Terrence E TE van der Post Sjoerd S Binkley Jana M JM Schwartz Drew J DJ Miyoshi Hiroyuki H Mack Matthias M Schwendener Reto A RA Hooton Thomas M TM Stappenbeck Thaddeus S TS Hansson Gunnar C GC Stenson William F WF Colonna Marco M Stapleton Ann E AE Hultgren Scott J SJ
EBioMedicine 20141024 1
The spread of multidrug-resistant microorganisms globally has created an urgent need for novel therapeutic strategies to combat urinary tract infections (UTIs). Immunomodulatory therapy may provide benefit, as treatment of mice with dexamethasone during acute UTI improved outcome by reducing the development of chronic cystitis, which predisposes to recurrent infection. Here we discovered soluble biomarkers engaged in myeloid cell development and chemotaxis that were predictive of future UTI recu ...[more]