Ontology highlight
ABSTRACT:
SUBMITTER: Nowag H
PROVIDER: S-EPMC4457436 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
EBioMedicine 20141108 2-3
Epstein Barr virus (EBV) persists as a latent herpes virus infection in the majority of the adult human population. The virus can reactivate from this latent infection into lytic replication for virus particle production. Here, we report that autophagic membranes, which engulf cytoplasmic constituents during macroautophagy and transport them to lysosomal degradation, are stabilized by lytic EBV replication in infected epithelial and B cells. Inhibition of autophagic membrane formation compromise ...[more]