Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4457472 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Li Jianxue J Gu Xuesong X Ma Yinghua Y Calicchio Monica L ML Kong Dong D Teng Yang D YD Yu Lili L Crain Andrew M AM Vartanian Timothy K TK Pasqualini Renata R Arap Wadih W Libermann Towia A TA Snyder Evan Y EY Sidman Richard L RL
Neuron 20101001 1
The molecular pathways controlling cerebellar Purkinje cell dendrite formation and maturation are poorly understood. The Purkinje cell degeneration (pcd) mutant mouse is characterized by mutations in Nna1, a gene discovered in an axonal regenerative context, but whose actual function in development and disease is unknown. We found abnormal development of Purkinje cell dendrites in postnatal pcd(Sid) mice and linked this deficit to a deletion mutation in exon 7 of Nna1. With single cell gene prof ...[more]