Ontology highlight
ABSTRACT:
SUBMITTER: Wong VW
PROVIDER: S-EPMC4457506 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Wong Victor W VW Rustad Kristine C KC Akaishi Satoshi S Sorkin Michael M Glotzbach Jason P JP Januszyk Michael M Nelson Emily R ER Levi Kemal K Paterno Josemaria J Vial Ivan N IN Kuang Anna A AA Longaker Michael T MT Gurtner Geoffrey C GC
Nature medicine 20111211 1
Exuberant fibroproliferation is a common complication after injury for reasons that are not well understood. One key component of wound repair that is often overlooked is mechanical force, which regulates cell-matrix interactions through intracellular focal adhesion components, including focal adhesion kinase (FAK). Here we report that FAK is activated after cutaneous injury and that this process is potentiated by mechanical loading. Fibroblast-specific FAK knockout mice have substantially less ...[more]