Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy.
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ABSTRACT:
SUBMITTER: Lamb AL
PROVIDER: S-EPMC4457648 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy.
Biochimica et biophysica acta 20150510 8
The rise of antibiotic resistance is a growing public health crisis. Novel antimicrobials are sought, preferably developing nontraditional chemical scaffolds that do not inhibit standard targets such as cell wall synthesis or the ribosome. Iron scavenging has been proposed as a viable target, because bacterial and fungal pathogens must overcome the nutritional immunity of the host to be virulent. This review highlights the recent work toward exploiting the biosynthetic enzymes of siderophore pro ...[more]
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