Association study of genetic variants at newly identified lipid gene TRIB1 with coronary heart disease in Chinese Han population.

ABSTRACT:

Background

Recent genome-wide association studies (GWAS) have identified the variants near TRIB1 gene affecting blood lipid levels. However, the association between the reported variants and risk of coronary heart disease (CHD) was not confirmed.

Methods

We conducted two independent case-control studies. The first study consisted of 300 CHD patients and 300 controls and the second study had 1,332 CHD patients and 2,811 controls. The genotypes of two variants rs3201475 and rs17321515 in TRIB1 were determined by TaqMan assay. The dual-luciferase reporter assay was performed for evaluating the function of the SNP rs3201475.

Results

The statistical analysis indicated that single nucleotide polymorphism (SNP) rs17321515 was replicated to be associated with triglyceride (TG

SUBMITTER: Wang L 

PROVIDER: S-EPMC4457977 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature