Ontology highlight
ABSTRACT:
SUBMITTER: Phad GE
PROVIDER: S-EPMC4458414 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Phad Ganesh E GE Vázquez Bernat Néstor N Feng Yu Y Ingale Jidnyasa J Martinez Murillo Paola Andrea PA O'Dell Sijy S Li Yuxing Y Mascola John R JR Sundling Christopher C Wyatt Richard T RT Karlsson Hedestam Gunilla B GB
Journal of immunology (Baltimore, Md. : 1950) 20150511 12
Isolation of mAbs elicited by vaccination provides opportunities to define the development of effective immunity. Ab responses elicited by current HIV-1 envelope glycoprotein (Env) immunogens display narrow neutralizing activity with limited capacity to block infection by tier 2 viruses. Intense work in the field suggests that improved Env immunogens are forthcoming, and it is therefore important to concurrently develop approaches to investigate the quality of vaccine-elicited responses at a hig ...[more]