Unknown

Dataset Information

0

Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses.

ABSTRACT: In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.

SUBMITTER: Saravanan S 

PROVIDER: S-EPMC4458742 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses.

Saravanan Shanmugam S   Gomathi Selvamurthi S   Kausalya Bagavathi B   Boobalan Jayaseelan J   Murugavel Kailapuri G KG   Balakrishnan Pachamuthu P   Mothi Sarvode N SN   Solomon Sunil S SS   Kumarasamy Nagalingeswaran N   Selvamuthu Poongulali P   Solomon Suniti S   Smith Davey M DM  

AIDS research and human retroviruses 20150428 6

In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region. ...[more]

Similar Datasets

Unknown Different Effects of Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutations on Cytotoxic T Lymphocyte Recognition between HIV-1 Subtype B and Subtype A/E Infections.
| S-EPMC4473554 | biostudies-literature
Unknown Cytotoxic T cell immunity against telomerase reverse transcriptase in humans.
| S-EPMC18312 | biostudies-literature
Unknown HIV-1 subtype B protease and reverse transcriptase amino acid covariation.
| S-EPMC1866358 | biostudies-literature
Unknown Impact of the N348I mutation in HIV-1 reverse transcriptase on nonnucleoside reverse transcriptase inhibitor resistance in non-subtype B HIV-1.
| S-EPMC3067126 | biostudies-literature
Unknown Frequent emergence of N348I in HIV-1 subtype C reverse transcriptase with failure of initial therapy reduces susceptibility to reverse-transcriptase inhibitors.
| S-EPMC3491849 | biostudies-literature
Unknown Human immunodeficiency virus type 1 subtype F reverse transcriptase sequence and drug susceptibility.
| S-EPMC109572 | biostudies-literature
Transcriptomics Evolution of a Reverse Transcriptase to Map N1-Methyladenosine in Human mRNA
2019-09-24 | GSE123365 | GEO
Unknown Magnitude and frequency of cytotoxic T-lymphocyte responses: identification of immunodominant regions of human immunodeficiency virus type 1 subtype C.
| S-EPMC136554 | biostudies-literature
Unknown Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens.
| S-EPMC11796363 | biostudies-literature
Unknown The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.
| S-EPMC1149439 | biostudies-literature