Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses.
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ABSTRACT:
SUBMITTER: Saravanan S
PROVIDER: S-EPMC4458742 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
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Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses.
Saravanan Shanmugam S Gomathi Selvamurthi S Kausalya Bagavathi B Boobalan Jayaseelan J Murugavel Kailapuri G KG Balakrishnan Pachamuthu P Mothi Sarvode N SN Solomon Sunil S SS Kumarasamy Nagalingeswaran N Selvamuthu Poongulali P Solomon Suniti S Smith Davey M DM
AIDS research and human retroviruses 20150428 6
In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region. ...[more]
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