Ontology highlight
ABSTRACT:
SUBMITTER: Chernobrovkin A
PROVIDER: S-EPMC4459150 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Chernobrovkin Alexey A Marin-Vicente Consuelo C Visa Neus N Zubarev Roman A RA
Scientific reports 20150608
Phenomenological screening of small molecule libraries for anticancer activity yields potentially interesting candidate molecules, with a bottleneck in the determination of drug targets and the mechanism of anticancer action. We have found that, for the protein target of a small-molecule drug, the abundance change in late apoptosis is exceptional compared to the expectations based on the abundances of co-regulated proteins. Based on this finding, a novel method to drug target deconvolution is pr ...[more]