Ontology highlight
ABSTRACT:
SUBMITTER: Tang GB
PROVIDER: S-EPMC4459185 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Tang Gang-Bin GB Tang Xiang-Fang XF Li Kui K Wang De-Hua DH
Scientific reports 20150608
Most small homotherms display low leptin level in response to chronic cold exposure. Cold-induced hypoleptinemia was proved to induce hyperphagia. However, it is still not clear whether hypoleptinemia regulates energy expenditure in cold condition. We try to answer this question in chronic cold-acclimated rats. Results showed that 5-day intracerebroventricular(ICV) infusion of leptin (5 μg/day) had no effects on basal and adaptive thermogenesis and uncoupling protein 1 expression. Physical activ ...[more]