Ontology highlight
ABSTRACT:
SUBMITTER: Yokoyama JS
PROVIDER: S-EPMC4459447 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Yokoyama Jennifer S JS Bonham Luke W LW Sears Renee L RL Klein Eric E Karydas Anna A Kramer Joel H JH Miller Bruce L BL Coppola Giovanni G
BMC neurology 20150328
<h4>Background</h4>Heritability of Alzheimer's disease (AD) is estimated at 74% and genetic contributors have been widely sought. The ε4 allele of apolipoprotein E (APOE) remains the strongest common risk factor for AD, with numerous other common variants contributing only modest risk for disease. Variability in clinical presentation of AD, which is typically amnestic (AmnAD) but can less commonly involve visuospatial, language and/or dysexecutive syndromes (atypical or AtAD), further complicate ...[more]