Ontology highlight
ABSTRACT:
SUBMITTER: Ahn EH
PROVIDER: S-EPMC4459500 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Ahn Eun Hyun EH Kim Younghoon Y Kshitiz An Steven S SS Afzal Junaid J Lee Suengwon S Kwak Moonkyu M Suh Kahp-Yang KY Kim Deok-Ho DH Levchenko Andre A
Biomaterials 20131231 8
Adult stem cells hold great promise as a source of diverse terminally differentiated cell types for tissue engineering applications. However, due to the complexity of chemical and mechanical cues specifying differentiation outcomes, development of arbitrarily complex geometric and structural arrangements of cells, adopting multiple fates from the same initial stem cell population, has been difficult. Here, we show that the topography of the cell adhesion substratum can be an instructive cue to a ...[more]