Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez F
PROVIDER: S-EPMC4459503 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Fernandez Fabian F Lu Derek D Ha Phong P Costacurta Patricia P Chavez Renee R Heller H Craig HC Ruby Norman F NF
Science (New York, N.Y.) 20141101 6211
Chronic circadian dysfunction impairs declarative memory in humans but has little effect in common rodent models of arrhythmia caused by clock gene knockouts or surgical ablation of the suprachiasmatic nucleus (SCN). An important problem overlooked in these translational models is that human dysrhythmia occurs while SCN circuitry is genetically and neurologically intact. Siberian hamsters (Phodopus sungorus) are particularly well suited for translational studies because they can be made arrhythm ...[more]