Ontology highlight
ABSTRACT:
SUBMITTER: Penthala NR
PROVIDER: S-EPMC4459527 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20150516 14
Heteroaromatic analogs of DMU-212 (8-15) have been synthesized and evaluated for their anti-cancer activity against a panel of 60 human cancer cell lines. These novel analogs contain a trans-3,4,5-trimethoxystyryl moiety attached to the C2 position of indole, benzofuran, benzothiazole or benzothiophene ring (8, 11, 13 and 14, respectively) and showed potent growth inhibition in 85% of the cancer cell lines examined, with GI50 values <1 μM. Interestingly, trans-3,4- and trans-3,5-dimethoxystyryl ...[more]