Testing for rare variant associations in the presence of missing data.
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ABSTRACT:
SUBMITTER: Auer PL
PROVIDER: S-EPMC4459641 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Testing for rare variant associations in the presence of missing data.
Auer Paul L PL Wang Gao G Leal Suzanne M SM
Genetic epidemiology 20130611 6
For studies of genetically complex diseases, many association methods have been developed to analyze rare variants. When variant calls are missing, naïve implementation of rare variant association (RVA) methods may lead to inflated type I error rates as well as a reduction in power. To overcome these problems, we developed extensions for four commonly used RVA tests. Data from the National Heart Lung and Blood Institute-Exome Sequencing Project were used to demonstrate that missing variant calls ...[more]
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