Association between major depression and type 2 diabetes in midlife: findings from the Screening Across the Lifespan Twin Study.

ABSTRACT:

Objective

Cohort studies suggest that the relationship between major depression (MD) and Type 2 diabetes (T2DM) is bidirectional. However, this association may be confounded by shared genetic or environmental factors. The objective of this study was to use a twin design to investigate the association between MD and T2DM.

Methods

Data come from the Screening Across the Lifespan Twin Study, a sample of monozygotic and dizygotic twins 40 years or older sampled from the Swedish Twin Registry (n = 37,043). MD was assessed by using the Composite International Diagnostic Inventory. Structural equation twin modeling and Cox proportional hazards modeling were used to assess the relationship between MD and T2DM.

Results

Approximately 19% of respondents had a history of MD and 5

SUBMITTER: Mezuk B 

PROVIDER: S-EPMC4459909 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature