Ontology highlight
ABSTRACT:
SUBMITTER: Gottipati MK
PROVIDER: S-EPMC4459931 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Gottipati Manoj K MK Bekyarova Elena E Haddon Robert C RC Parpura Vladimir V
Amino acids 20150403 7
Using a radioactive glutamate uptake assay and immunolabeling, we report that single-walled carbon nanotubes, chemically functionalized with polyethylene glycol (SWCNT-PEG), delivered as a colloidal solute, cause an increase in the uptake of extracellular glutamate by astrocytes and an increase in the immunoreactivity of the glutamate transporter GLAST on their cell surface, which is likely a consequence of an increase in the immunoreactivity of glial fibrillary acidic protein. Additional coroll ...[more]