Angiotensin II inhibitor facilitates epidermal wound regeneration in diabetic mice.
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ABSTRACT:
SUBMITTER: Kamber M
PROVIDER: S-EPMC4460301 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Angiotensin II inhibitor facilitates epidermal wound regeneration in diabetic mice.
Kamber Maria M Papalazarou Vasileios V Rouni Georgia G Papageorgopoulou Evagelia E Papalois Apostolos A Kostourou Vassiliki V
Frontiers in physiology 20150609
Tissue regeneration and wound healing are severely impaired in diabetes and are associated with poor circulation and dysfunctional blood vessels. Angiotensin II inhibitors are anti-hypertensive drugs used in clinical practice to regulate blood pressure and could affect tissue remodeling. We hypothesize that blocking angiotensin II, using Losartan, could facilitate tissue regeneration in diabetic mice. To this end, we established an experimental model of wound healing in streptozotocin-induced di ...[more]
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