Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki T
PROVIDER: S-EPMC4460459 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Suzuki Takashi T Suzuki Miho M Ogino Shinji S Umemoto Ryo R Nishida Noritaka N Shimada Ichio I
Proceedings of the National Academy of Sciences of the United States of America 20150518 22
CD44 is the receptor for hyaluronan (HA) and mediates cell rolling under fluid shear stress. The HA-binding domain (HABD) of CD44 interconverts between a low-affinity, ordered (O) state and a high-affinity, partially disordered (PD) state, by the conformational change of the C-terminal region, which is connected to the plasma membrane. To examine the role of tensile force on CD44-mediated rolling, we used a cell-free rolling system, in which recombinant HABDs were attached to beads through a C-t ...[more]