Ontology highlight
ABSTRACT:
SUBMITTER: Wong A
PROVIDER: S-EPMC4460814 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Wong Aloysius A Gehring Chris C Irving Helen R HR
Frontiers in bioengineering and biotechnology 20150609
Moonlighting functional centers within proteins can provide them with hitherto unrecognized functions. Here, we review how hidden moonlighting functional centers, which we define as binding sites that have catalytic activity or regulate protein function in a novel manner, can be identified using targeted bioinformatic searches. Functional motifs used in such searches include amino acid residues that are conserved across species and many of which have been assigned functional roles based on exper ...[more]