Automated Solution-Phase Synthesis of β-1,4-Mannuronate and β-1,4-Mannan.
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ABSTRACT: The first automated solution-phase synthesis of β-1,4-mannuronate and β-1,4-mannan oligomers has been accomplished by using a β-directing C-5 carboxylate strategy. By utilizing fluorous-tag assisting purification after repeated reaction cycles, β-1,4-mannuronate was synthesized up to a hexasaccharide with limited loading of a glycosyl donor (up to 3.5 equiv) for each glycosylation cycle due to the homogeneous solution-phase reaction condition. After a global reduction of the uronates, the β-1,4-mannan hexasaccharide was obtained, thereby demonstrating a new approach to β-mannan synthesis.
SUBMITTER: Tang SL
PROVIDER: S-EPMC4460921 | biostudies-literature |
REPOSITORIES: biostudies-literature
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