Ontology highlight
ABSTRACT:
SUBMITTER: Qi W
PROVIDER: S-EPMC4461055 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Qi Wen W Chen Fangfang F Sun Jiahong J Simpkins James W JW Yuan Dan D
Planta medica 20141217 1
Isocorynoxeine, one of the major alkaloids from Uncaria Hook, shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. In this paper, the metabolism of isocorynoxeine was investigated in rats. Twelve metabolites and the parent drug were isolated by using solvent extraction and repeated chromatographic methods, and determined by spectroscopic methods including UV, MS, NMR, and CD experiments. Seven new compounds were identified as 11-h ...[more]