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MicroRNAs as therapeutic targets in human cancers.

ABSTRACT: MicroRNAs (miRNAs) are evolutionarily conserved, small, regulatory RNAs that negatively regulate gene expression. Extensive research in the last decade has implicated miRNAs as master regulators of cellular processes with essential role in cancer initiation, progression, and metastasis, making them promising therapeutic tools for cancer management. In this article, we will briefly review the structure, biogenesis, functions, and mechanism of action of these miRNAs, followed by a detailed analysis of the therapeutic potential of these miRNAs. We will focus on the strategies presently used for miRNA therapy; discuss their use and drawbacks; and the challenges and future directions for the development of miRNA-based therapy for human cancers.

SUBMITTER: Shah MY

PROVIDER: S-EPMC4461221 | biostudies-literature | 2014 Jul-Aug

REPOSITORIES: biostudies-literature

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MicroRNAs as therapeutic targets in human cancers.

Shah Maitri Y MY Calin George A GA Calin George A GA

Wiley interdisciplinary reviews. RNA 20140328 4

MicroRNAs (miRNAs) are evolutionarily conserved, small, regulatory RNAs that negatively regulate gene expression. Extensive research in the last decade has implicated miRNAs as master regulators of cellular processes with essential role in cancer initiation, progression, and metastasis, making them promising therapeutic tools for cancer management. In this article, we will briefly review the structure, biogenesis, functions, and mechanism of action of these miRNAs, followed by a detailed analysi ...[more]

PMID: 24687772

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