Ontology highlight
ABSTRACT:
SUBMITTER: Torregrosa R
PROVIDER: S-EPMC4461516 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Torregrosa Robert R Yang Xiao-Fang XF Dustrude Erik T ET Cummins Theodore R TR Khanna Rajesh R Kohn Harold H
Bioorganic & medicinal chemistry 20150411 13
Six novel 3″-substituted (R)-N-(phenoxybenzyl) 2-N-acetamido-3-methoxypropionamides were prepared and then assessed using whole-cell, patch-clamp electrophysiology for their anticonvulsant activities in animal seizure models and for their sodium channel activities. We found compounds with various substituents at the terminal aromatic ring that had excellent anticonvulsant activity. Of these compounds, (R)-N-4'-((3″-chloro)phenoxy)benzyl 2-N-acetamido-3-methoxypropionamide ((R)-5) and (R)-N-4'-(( ...[more]