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Radiofrequency Volumetric Thermal Ablation of Fibroids and Laparoscopic Myomectomy: Long-Term Follow-up From a Randomized Trial.


ABSTRACT: Aims: Laparoscopic myomectomy (LM) has been the gold standard treatment for uterine fibroids in women desiring uterine conservation. To evaluate a new fibroid treatment modality - radiofrequency volumetric thermal ablation (RFVTA) - we compare 12-month results in women who had symptomatic uterine fibroids and who were randomized to laparoscopic ultrasound-guided RFVTA or LM. Materials and Methods: Our study is a 1?:?1 parallel, randomized, prospective, single-center, longitudinal, comparative analysis of RFVTA to LM for fibroid treatment in women ??18 years of age who desired uterine conservation. Fifty women were randomized intraoperatively to RFVTA (n?=?25) or to LM (n?=?25) after laparoscopic ultrasound mapping of the uterus. Results: Post surgery, ablation and myomectomy subjects took pain medications for 4 days (range: 1-46) and 7 days (range: 1-83 days) respectively (p?=?0.60). Ablation and myomectomy subjects missed 10.0 workdays (range: 2-86 days) and 17.0 workdays (range: 7-30 days) (p?=?0.28), resumed normal activities in 20.5 days (range: 5-103 days) versus 28.0 days (range: 10-42 days) (p?=?0.86) respectively. Mean symptom severity scores decreased (improved) by -?7.8 for the ablation subjects and by -?17.9 for the myomectomy subjects (p?=?0.16). Health-related quality of life improved (increased) by 7.5 and 13.1, respectively, for the two groups (p?=?0.46). Two myomectomy subjects had pregnancies that ended in a Cesarean delivery and a vaginal delivery of healthy infants. Two pregnancies in the RFVTA group ended in full-term vaginal deliveries of healthy infants. Conclusions: Early postoperative recovery and twelve-month results attest to similar clinical benefits from RFVTA and LM.

SUBMITTER: Hahn M 

PROVIDER: S-EPMC4461677 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Radiofrequency Volumetric Thermal Ablation of Fibroids and Laparoscopic Myomectomy: Long-Term Follow-up From a Randomized Trial.

Hahn M M   Brucker S S   Kraemer D D   Wallwiener M M   Taran F-A FA   Wallwiener C W CW   Krämer B B  

Geburtshilfe und Frauenheilkunde 20150501 5


<b>Aims:</b> Laparoscopic myomectomy (LM) has been the gold standard treatment for uterine fibroids in women desiring uterine conservation. To evaluate a new fibroid treatment modality - radiofrequency volumetric thermal ablation (RFVTA) - we compare 12-month results in women who had symptomatic uterine fibroids and who were randomized to laparoscopic ultrasound-guided RFVTA or LM. <b>Materials and Methods:</b> Our study is a 1 : 1 parallel, randomized, prospective, single-center, longitudinal,  ...[more]

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